Longitudinal Development of Hormone Levels and Grey Matter Density in 9 and 12-Year-Old Twins
نویسندگان
چکیده
Puberty is characterized by major changes in hormone levels and structural changes in the brain. To what extent these changes are associated and to what extent genes or environmental influences drive such an association is not clear. We acquired circulating levels of luteinizing hormone, follicle stimulating hormone (FSH), estradiol and testosterone and magnetic resonance images of the brain from 190 twins at age 9 [9.2 (0.11) years; 99 females/91 males]. This protocol was repeated at age 12 [12.1 (0.26) years] in 125 of these children (59 females/66 males). Using voxel-based morphometry, we tested whether circulating hormone levels are associated with grey matter density in boys and girls in a longitudinal, genetically informative design. In girls, changes in FSH level between the age of 9 and 12 positively associated with changes in grey matter density in areas covering the left hippocampus, left (pre)frontal areas, right cerebellum, and left anterior cingulate and precuneus. This association was mainly driven by environmental factors unique to the individual (i.e. the non-shared environment). In 12-year-old girls, a higher level of circulating estradiol levels was associated with lower grey matter density in frontal and parietal areas. This association was driven by environmental factors shared among the members of a twin pair. These findings show a pattern of physical and brain development going hand in hand.
منابع مشابه
Longitudinal study of hormonal and physical development in young twins.
CONTEXT AND OBJECTIVE Information on the correlation of normative reproductive hormone levels with physical development (Tanner stages) during puberty and on the influences of genes and environment on variation in these hormones and Tanner stages is limited. DESIGN, SETTING, AND PARTICIPANTS One hundred twelve healthy 9-year-old twin pairs (n = 224) took part in a longitudinal study, of which...
متن کاملGenetic and environmental influences on focal brain density in bipolar disorder.
Structural neuroimaging studies suggest the presence of subtle abnormalities in the brains of patients with bipolar disorder. The influence of genetic and/or environmental factors on these brain abnormalities is unknown. To investigate the contribution of genetic and environmental factors on grey and white matter brain densities in bipolar disorder, monozygotic and dizygotic twins concordant an...
متن کاملTHE EFFECT OF GENETIC AL AND ENVIRONMENTAL FACTORS ON LIPIDS: A TWIN STUDY
To assess the relative contribution of genetic and environmental factors (particularly androgens) on circulating levels of lipid fractions, serum androgen and lipid fractions were measured in 34 pairs of female-female twins aged from 15- 45 years, some of whom were discordant for polycystic ovary syndrome (PCOS) diagnosed by ultrasound. Nineteen pairs were monozygotic twins (MZ) and 15 pai...
متن کاملCerebral white matter in early puberty is associated with luteinizing hormone concentrations.
Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Volumetric ...
متن کاملBrain Structural Correlates of INTELLIGENCE in ADHD Individuals
Neuroimaging evidences have shown the association of intelligence with several structural brain properties in normal individuals. However, this association for attention deficit hyperactivity disorder (ADHD) is need to be investigated. we estimated grey matter density of the brain using MRI scanning on 56 ADHD individuals comprising 30 combined (age=10.44±2.41, IQ=112.13±13.15, male, 24 right h...
متن کامل